中心主任

姓名 : 楊慕華

聯絡電話 : +886-2-28712121 ext. 7911/6510

電子郵件 : mhyang2@vghtpe.gov.tw

聯絡地址:11221 台北市北投區立農街二段155號國立陽明大學守仁樓2樓203室(臨床醫學研究所)

現職:

國立陽明大學/副校長

臺北榮民總醫院/腫瘤醫學部藥物治療科主任

國立陽明大學腫瘤惡化卓越研究中心/主任

國立陽明大學臨床醫學研究所/講座教授

中央研究院基因體中心/合聘研究員

學歷:

國立陽明大學臨床醫學研究所博士 (2003-2006)

國立陽明大學醫學系醫學士 (1987-1994)

研究領域:

頭頸癌、臨床腫瘤學、癌症生物學、細胞生物學、分子生物學

Cancer Biology, Medical Oncology, Hematology, Internal medicine, Head and Neck cancer 

代表性著作目錄

1. Li CF, Chen JY, Ho YH, Hsu WH, Wu LC, Lan HY, Hsu DS, Tai SK, Chang YC*, Yang MH*. Snail-induced claudin-11 prompts collective migration for tumour progression. Nat Cell Biol. 2019 Feb;21(2):251-262. (*: co-corresponding author)

2. Lee CC, Lin JC, Hwang WL, Kuo YJ, Chen HK, Tai SK, Lin CC, Yang MH*. Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization. Nat Commun. 2018 Sep 14;9(1):3763. (*: corresponding author)

3. Pan YR, Chen CC, Chan YT, Wang HJ, Chien FT, Chen YL, Liu JL, Yang MH*. STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas. Nat Commun. 2018 Sep 12;9(1):3696. (*: corresponding author)

4. Hsieh CH, Tai SK, Yang MH*. Snail-overexpressing Cancer Cells Promote M2-Like Polarization of Tumor-Associated Macrophages by Delivering MiR-21-Abundant Exosomes. Neoplasia. 2018 Jul 2;20(8):775-788. (*: corresponding author)

5. Hsu DS, Hwang WL, Yuh CH, Chu CH, Ho YH, Chen PB, Lin HS, Lin HK, Wu SP, Lin CY, Hsu WH, Lan HY, Wang HJ, Tai SK, Hung MC, Yang MH*. Lymphotoxin-beta interacts with methylated EGFR to mediate acquired resistance to cetuximab in head and neck cancer. Clin Cancer Res. 2017 Aug 1;23(15):4388-4401. (*: corresponding author). 

6. Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH*. let-7 modulates chromatin configuration and target gene repression through regulation of the ARID3B complex. Cell Rep. 2016;14:520-533. (*: corresponding author). 

7.  Hsu DS, Wang SJ, Tai SK, Chou CH, Hsieh CH, Chiu PH, Chen NJ, Yang MH*. Acetylation of Snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell 2014;26:534-548 (*:corresponding author). 

8.  Hwang WL, Jiang JK, Yang SH, Huang TS, Lan HY, Teng HW, Yang CY, Tsai YP, Lin CH, Wang HW*, Yang MH*. MicroRNA-146a directs the symmetrical division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol. 2014;16:268-280 (*: co-corresponding authors).

9. Yang WH, Lan SY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH*. RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol. 2012; 14: 366-374 (*: corresponding author).

10. Yang MH*, Hsu DS, Wang HW, Wang SJ, Lan HY, Yang WH, Huang CH, Kao SY, Tzeng CH, Tai SK, Chang SY, Lee OK, Wu KJ*. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol. 2010; 12:982-992 (*: corresponding author).

11.Yang MH,  Wu MZ, Chiou SH, Chen PM, Chang SY, Liu CJ, Teng SC, Wu KJ. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 2008; 10:295-305.